CAP ORGAN TECHNOLOGY
Better than cell-based assays, 3D tissue assemblies provide the best compromise between ease of use and in vivo-like drug responses. We manufacture human skin, bone, lung and intestine which is important for use as a model to develop medical treatments, consumer products and cosmetics.
Our technology yields early hair follicle formation using human skin cells placed under modified conditions. Evenly spaced cell clumps form as a visible placode, and are nanog positive in IHC staining. Below is a eosin-hematoxylin stained lab created full thickness skin. Dr. Hoeffler made a pivotal contribution in 2000 with his scientific paper entitled “Spontaneous Cell Sorting of Fibroblasts and Keratinocytes Creates an Organotypic Human Skin Equivalent”, advancing the concept of triggering cells to migrate into correct position, rather than attempting to position them using ‘inkjet’ printing technology, or consecutive layering. We received extensive criticism at the time, but now it’s used as the platform for organ creation in some of the best research.