HOF Therapeutics
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HOF Therapeutics assembles cells into tissues and multiple functional organ elements for applications in regenerative medicine and as biological assays for drug screening to investigate cancers and other diseases. As founders of the cell sorting paradigm for organ component creation, we now offer control over these systems through cell assembly programming (CAP), with applicability to multiple organs. Rethinking the basics of physiology has also empowered our systems with new information about blood vessel formation and fibrosis, and enabled cryogenics of multicellular living specimens. After decades of federal and state funding of stem cell therapy any implantation of cells requires patients to travel outside the U.S., unless enrolled in a clinical trial. This is a failure in current technology and indicates an unmet medical need that HOF Therapeutics provides for.
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TYPES OF TECHNOLOGY TO MAKE 3D ORGANS:
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1) Cell Assembly Programming (CAP) - CELLS RUN A GENETIC HEALING PROGRAM TO SELF MOVE INTO POSITION TO FORM CORRECT MICRO-PHYSIOLOGY, developed by HOF Therapeutics.
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2) Layered Method - Mesenchymal cells solidified in collagen, later epithelial cells layered on top, pseudo layers. Ex., Mattek sold to BICO
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3) Organoids - Contains stem cells and an exogenous matrix to make an inside-out ball or sphere, with no specific requirements to qualify.
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4) Gestational Organoids - embryonic stem cells can be taken through developmental steps even after an embryo is disrupted into stem cells. Months of precise timing of growth factor/cytokine treatments leads to 3D models. Not practical for large scale production.
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5) Inkjet or bio printing - placement of cells achieved using a computer driven printhead, for larger scale models. Less capable of producing fine structures such as glands and ducts. May benefit from CAP.